In the process, carbon dioxide is released and one molecule of NADH is formed. Upon entering the mitochondrial matrix, a multi-enzyme complex converts pyruvate into acetyl CoA. The enzyme-bound acetyl group is transferred to CoA, producing a molecule of acetyl CoA. The high-energy electrons from NADH will be used later to generate ATP. The hydroxyethyl group is oxidized to an acetyl group, and the electrons are picked up by NAD +, forming NADH. This step proceeds twice (remember: there are two pyruvate molecules produced at the end of glycolsis) for every molecule of glucose metabolized thus, two of the six carbons will have been removed at the end of both steps. This is the first of the six carbons from the original glucose molecule to be removed. The result of this step is a two-carbon hydroxyethyl group bound to the enzyme (pyruvate dehydrogenase). ![]() A carboxyl group is removed from pyruvate, releasing a molecule of carbon dioxide into the surrounding medium. ![]() ![]() The conversion is a three-step process ( Figure). In order for pyruvate, the product of glycolysis, to enter the next pathway, it must undergo several changes.
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